{"product_id":"sodium-hydrogen-carbonate-4-2-solution-for-infusion","title":"SODIUM HYDROGEN CARBONATE 4.2% solution for infusion","description":"\u003ch1\u003e\u003cspan\u003eSODIUM HYDROGEN CARBONATE 4.2% solution for infusion\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp\u003e\u003cspan\u003ePack size:\u003c\/span\u003e\u003cspan\u003e10 x 250 \u003c\/span\u003e\u003cspan\u003eml \u003c\/span\u003e\u003cspan\u003eDosage form:\u003c\/span\u003e\u003cspan\u003eInfusion solution \u003c\/span\u003e\u003cb\u003e\u003cspan\u003eSodium bicarbonate 4.2% B. Braun infusion solution.\u003c\/span\u003e\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIndications: Used to correct excessive blood acidity (metabolic acidosis), raise the pH of the urine (urine alkalization) in cases of poisoning with weak organic acids (e.g., barbiturates, acetylsalicylic acid), raise the pH of the urine (urine alkalization) to improve the solubility of medications that are poorly soluble in neutral and acidic environments (e.g., methotrexate, sulfonamides), raise the pH of the urine (urine alkalization) in cases of red blood cell breakdown (hemolysis).\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003e\u003cspan\u003eFor information on risks and side effects, read the package insert and ask your doctor or pharmacist.\u003c\/span\u003e\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003ePACKAGE LEAFLET: INFORMATION FOR THE USER\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eSodium bicarbonate 4.2% B. Braun infusion solution\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eActive ingredient: Sodium bicarbonate\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eRead the entire package leaflet carefully before you start using this medicine.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eKeep this leaflet. You may want to read it again later.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIf you have any further questions, ask your doctor or pharmacist.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIf any of the side effects listed affect you seriously or if you notice side effects not listed in this leaflet, please inform your doctor or pharmacist.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eThis package leaflet contains:\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\u003cspan\u003eWHAT IS SODIUM HYDROGEN CARBONATE 4.2% B. BRAUN AND WHAT IS IT USED FOR?\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eWHAT SHOULD YOU CONSIDER BEFORE USING SODIUM HYDROGEN CARBONATE 4.2% B. BRAUN?\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eHOW SHOULD SODIUM HYDROGEN CARBONATE 4.2% B. BRAUN BE USED?\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eWHAT SIDE EFFECTS ARE POSSIBLE?\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eHOW SHOULD SODIUM HYDROGEN CARBONATE 4.2% B. BRAUN BE STORED?\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMORE INFORMATION\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e1. WHAT IS SODIUM BIcarbonate 4.2% B. Braun AND WHAT IS IT USED FOR?\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eSodium Bicarbonate 4.2% B. Braun is a solution for raising blood pH (alkalinization) by administering bicarbonate. Sodium Bicarbonate 4.2% B. Braun is used for:\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eCorrection of hyperacidity of the blood (metabolic acidosis),\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIncrease in the pH value of the urine (urine alkalization) in case of poisoning with weak organic acids (e.g. barbiturates, acetylsalicylic acid),\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eRaising the pH value of the urine (urine alkalization) to improve the solubility of drugs that are poorly soluble in neutral and acidic environments (e.g. methotrexate, sulfonamides),\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIncrease in the pH value of the urine (urine alkalization) when red blood cells break down (hemolysis).\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eSodium bicarbonate 4.2% B. Braun is a medicine that will be administered to you by a doctor or healthcare professional.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e2. WHAT MUST YOU CONSIDER BEFORE USING SODIUM BIcarbonate 4.2% B. Braun?\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eSodium bicarbonate 4.2% B. Braun should not be used if:\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eExcess alkali in the blood (alkalosis),\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003elow potassium levels in the blood (hypokalemia),\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eincreased sodium levels in the blood (hypernatremia).\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eSpecial care is required when using sodium bicarbonate 4.2% B. Braun in the following cases:\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eslowed or shallow breathing (hypoventilation)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003elow calcium levels in the blood (hypocalcemia)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eConditions associated with increased concentration of salts in the blood (hyperosmolarity)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDiseases that require a limited sodium intake, such as heart failure, fluid accumulation in the tissues (generalized edema), fluid accumulation in the lungs (pulmonary edema), high blood pressure (hypertension), pregnancy-related conditions with high blood pressure, cramps and fluid accumulation in the tissues (eclampsia), severe kidney dysfunction (renal insufficiency).\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eMonitoring of serum electrolytes, fluid balance, and acid-base status is required. Administration of Sodium Bicarbonate 4.2% B. Braun can lead to high sodium and fluid load. Alkalizing therapy can cause the potassium level in the blood to fall below normal values (hypokalemia). In cases of low potassium or calcium levels in the blood (hypokalemia or hypocalcemia, respectively), the potassium or calcium deficiency should be corrected before alkalizing therapy. Particular care must be taken with strict intravenous administration, as accidental administration into an artery can lead to shock and loss of the affected limb.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eNewborns and children under 2 years of age:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eRapid infusions (up to 1 ml\/min) of hypertonic sodium bicarbonate solutions can cause excessively high concentrations of sodium in the blood (hypernatremia) and, in premature infants, cerebral hemorrhage. Therefore, your doctor will ensure that doses of \u0026gt; 5 mmol per kg body weight per day should not be administered (see also section 4.2). If used improperly, sodium bicarbonate 4.2% B. Braun may cause vein wall irritation with subsequent phlebitis and thrombophlebitis if applied too quickly into veins of the extremities (peripheral veins) due to its alkaline pH. If accidentally administered next to the vein (paravenously), tissue destruction (necrosis) may occur.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eWhen using sodium bicarbonate 4.2% B. Braun with other medicines:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003ePlease inform your doctor or pharmacist if you are taking or have recently taken or used any other medicines, including medicines obtained without a prescription. In particular, please inform your doctor if you are receiving or using the following medicines:\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eAdrenal cortex hormones,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAndrogens (male sex hormones),\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ediuretics that increase potassium excretion.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eThe increase in urine pH (alkalization) caused by bicarbonate accelerates the excretion of acidic drugs (e.g., acetylsalicylic acid) and delays the excretion of basic drugs. Due to its alkaline pH, Sodium Bicarbonate 4.2% B. Braun is physically and chemically incompatible with most drugs. In particular, combination with solutions containing calcium, magnesium, and phosphate can lead to precipitation.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003ePregnancy and breastfeeding:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003ePlease inform your doctor if you are pregnant or breastfeeding before treatment with Sodium Bicarbonate 4.2% B. Braun\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e. Pregnancy:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eSodium bicarbonate can be administered to you via infusion during pregnancy if your doctor considers this absolutely necessary after careful risk-benefit assessment. Due to the high sodium content of the solution, special caution is required in pregnancy-related illnesses with high blood pressure, cramps and fluid retention in the tissues (eclampsia) (see section “Special caution is required when using Sodium Bicarbonate 4.2% B. Braun”).\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eBreastfeeding:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eDuring breastfeeding, Sodium Bicarbonate 4.2% B. Braun should only be used with caution after careful benefit\/risk assessment.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eAbility to drive and operate machinery:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eSodium Bicarbonate 4.2% B. Braun has no influence on the ability to drive or operate machinery.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e3. HOW SHOULD SODIUM BIOCHEMICAL CARBONATE 4.2% B. BRAUN BE USED?\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eThis medicine will be administered to you by a doctor or medical professional.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eDosage:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eAdults:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eWhen correcting metabolic acidosis, the dosage depends on the extent of the disturbance in the acid-base status. Based on the blood gas analysis, the amount to be administered is calculated using the following formula: ml 0.5 molar sodium bicarbonate 4.2% B. Braun infusion solution = base deficit (-BE) × kg body weight × 0.3 × 2 (The factor 0.3 corresponds to the proportion of extracellular fluid in relation to total fluid, \"KG\", = body weight.)\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eChildren:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eYour doctor will determine the dosage for your child individually. Initially, a dosage of up to 1 mmol\/kg body weight can be selected, which is administered slowly into a vein (IV).\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eNewborns and children under 2 years:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eYour doctor will ensure that the dosage to be administered does not exceed 5 mmol\/kg body weight per day. The solution will then be given slowly into your child's vein and is generally diluted. Your doctor will ensure that a 4.2% (or less concentrated) sodium bicarbonate solution should generally be used in this age group.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eExample of use:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eA determined base deficit (BE) of, for example, -5 with a body weight of 70 kg results in: 5 × 70 × 0.3 × 2 = 210 ml Sodium Bicarbonate 4.2% B. Braun Infusion Solution. Since acidosis correction should not occur too quickly, i.e. full compensation of the base deficit should not be sought, it is recommended that half of the calculated amount of Sodium Bicarbonate 4.2% B. Braun Infusion Solution be administered initially and the next dose dependent on the results of further blood gas analyses.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eMaximum daily dose:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eThe maximum daily dose depends on the correction required.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eMaximum infusion rate:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eUp to approximately 3 ml of sodium bicarbonate 4.2% B. Braun infusion solution per kg body weight per hour. For urine alkalinization, the dosage is based on the desired pH value in the urine and is carried out under control of the acid-base, water and electrolyte balance. The maximum infusion rate stated above must not be exceeded.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eMethod of administration:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eIntravenous use, i.e. administration as an infusion into a vein.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eIf you use more sodium bicarbonate 4.2% B. Braun infusion solution than you should:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eAn overdose can lead to an excess of alkali in the blood (alkalosis), an increased sodium level in the blood (hypernatremia) and an increased salt concentration in the blood (hyperosmolarity). If excessive acidification of the blood (acidosis) is compensated for too quickly, particularly in the case of respiratory disorders, the rapid release of CO2 can temporarily intensify excessive acidification of the brain (cerebral acidosis).\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eCountermeasures:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eAlkalosis therapy depending on the severity: administration of isotonic sodium chloride solution, potassium supplementation, in severe alkalosis, infusion of L-arginine hydrochloride or hydrochloric acid.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eIf you have any further questions on the use of this medicine, ask your doctor or pharmacist.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e4. POSSIBLE SIDE EFFECTS?\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eLike all medicines, Sodium Bicarbonate 4.2% B. Braun Infusion Solution can cause side effects, although not everybody experiences them. The following categories are used to estimate the frequency of side effects:\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"table-wrapper\"\u003e\n\u003ctable width=\"100%\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd colspan='\\\"2\\\"'\u003e\u003cspan\u003eThe following categories are used to indicate the frequency of side effects:\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003eVery common:\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003emore than 1 in 10 treated patients\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003eFrequently:\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003e1 to 10 treated patients out of 100\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003eOccasionally:\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003e1 to 10 patients treated in 1,000\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003eRarely:\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003e1 to 10 treated patients out of 10,000\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003eVery rare:\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003eless than 1 in 10,000 treated\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003eNot known:\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003eFrequency cannot be estimated based on the available data.\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003ePossible side effects:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eMetabolism and nutritional disorders:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eNot known: Use may lead to increased sodium levels in the blood (hypernatremia) and excessive salt concentration in the blood.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eReporting of side effects:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eIf you notice any side effects, contact your doctor or pharmacist. This also applies to side effects not listed in this package leaflet. You can also report side effects directly to the Federal Institute for Drugs and Medical Devices, Pharmacovigilance Department, Kurt-Georg-Kiesinger Allee 3, D-53175 Bonn. By reporting side effects, you can help provide more information on the safety of this medicine.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e5. HOW SHOULD SODIUM HYDROGEN CARBONATE 4.2% B. BRAUN SOLUTION FOR INFUSION BE STORED?\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eKeep out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and the container after “EXP”. The expiry date refers to the last day of the month. Storage conditions: This medicinal product does not require any special storage conditions. Information on shelf life after opening or preparation: For single use! Discard any remainder! Only use if the container is undamaged and the solution is clear.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003e6. FURTHER INFORMATION\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eWhat Sodium Hydrogen Carbonate 4.2% B. Braun Infusion Solution contains:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eThe active ingredient is sodium hydrogen carbonate (sodium bicarbonate). 1000 ml of infusion solution contains 42.0 g of sodium hydrogen carbonate (sodium bicarbonate). The other ingredients are: Disodium edetate (Ph. Eur.) 25 mg\/1000 ml, water for injections. Electrolytes: 500 mmol\/l sodium ion, 500 bicarbonate ion. Theoretical osmolarity: 1000 mOsm\/l. Titration acidity (pH 7.4): approx. -35 mmol\/l. pH value: 7.0 – 8.5.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eWhat Sodium Bicarbonate 4.2% B. Braun Infusion Solution looks like and what the pack contains:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eSodium Bicarbonate 4.2% B. Braun Infusion Solution is an infusion solution, i.e., a solution for administration via a cannula into a vein. It is a clear, colorless, aqueous solution. It is supplied in 250 ml glass bottles, in packs of 1 x 250 ml and 10 x 250 ml.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003ePharmaceutical Entrepreneur and Manufacturer:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eB. Braun Melsungen AG\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eCarl-Braun-Straße 1\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e34212 Melsungen\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003ePostal Address:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e34209 Melsungen\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eThis package leaflet was last revised in July 2025.\u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eSource: Information from the package leaflet\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e, as of: 08\/2025\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAreas of application: is used to correct hyperacidity of the blood (metabolic acidosis), to raise the pH value of the urine (urine alkalization) in cases of poisoning with weak organic acids (e.g. barbiturates, acetylsalicylic acid), to raise the pH value of the urine (urine alkalization) to improve the solubility of medications that are difficult to dissolve in neutral and acidic environments (e.g. methotrexate, sulfonamides), to raise the pH value of the urine (urine alkalization) in cases of red blood cell breakdown (hemolysis).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFor the correction of metabolic acidosis\u003c\/span\u003e\u003c\/p\u003e\n\u003csection class=\"text-dark-primary-max\"\u003e\n\u003ch3 class=\"text-s font-medium\"\u003e\u003cspan\u003eActive ingredients\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul class=\"mb-3.5 list-disc pl-5 text-s\"\u003e\n\u003cli\u003e\u003cspan\u003e10500 mg sodium bicarbonate\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/section\u003e\n\u003csection class=\"text-dark-primary-max\"\u003e\n\u003ch3 class=\"text-s font-medium\"\u003e\u003cspan\u003eExcipients\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul class=\"mb-3.5 list-disc pl-5 text-s\"\u003e\n\u003cli\u003e\u003cspan\u003eWater for injections\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e6.25 mg disodium edetate dihydrate\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eActive ingredient\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003esodium bicarbonate\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eElectrolyte solution for intravenous infusion\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eSodium bicarbonate 4.2% brown\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eFor the correction of metabolic acidosis\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFor urine alkalization in cases of intoxication with weak organic acids (e.g. barbiturates, acetylsalicylic acid)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFor urine alkalization to improve the solubility of medications that are poorly soluble in neutral and acidic environments (e.g. methotrexate, sulfonamides)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFor urine alkalization in hemolysis\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eWith 0.5 mmol\/ml sodium and 0.5 mmol\/ml bicarbonate\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cspan\u003eSODIUM HYDROGEN CARBONATE 4.2% solution for infusion\u003c\/span\u003e\u003c\/h2\u003e\n\u003c\/section\u003e","brand":"B. Braun Melsungen AG","offers":[{"title":"Default Title","offer_id":55517441622393,"sku":"01600423","price":155.25,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0903\/0792\/0249\/files\/SODIUMHYDROGENCARBONATE4.2_solutionforinfusion.webp?v=1753303823","url":"https:\/\/ukdorf.co.uk\/products\/sodium-hydrogen-carbonate-4-2-solution-for-infusion","provider":"UKDorf (ELIVERA) Buy online, Reviews Est. 1988 London, UK.","version":"1.0","type":"link"}