{"product_id":"leucovorin-15-mg-tablets-10-calcium-folinate","title":"LEUCOVORIN 15 mg tablets 10 Calcium folinate","description":"\u003ch1 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eLEUCOVORIN Calcium folinate 10 pc\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eThe active ingredient is: Calcium folinate 5 H2O1 tablet contains 19.06 mg calcium folinate 5 H2O equivalent to 15 mg folinic acid. — The other ingredients are: lactose monohydrate, cellulose powder, poly (ocarboxymethyl) starch sodium salt, corn starch partially sugar-coated, magnesium stearate\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/h2\u003e\n\u003ch2 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eLEUCOVORIN Calcium folinate Application areas:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eLeucovorin tablets are a detoxifying agent when using certain drugs to treat cancer and a means of preventing folic acid deficiency symptoms.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eLEUCOVORIN Calcium folinate tablets are used for that\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e1. Prevention of symptoms of poisoning with (medium-) high-dose methotrexate therapy or with persistently high methotrexate serum levels (also with low-dose methotrexate therapies).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 class=\"a-h4 u-no-margin u-font-weight--bold\"\u003e\u003cspan\u003eactive ingredients\u003c\/span\u003e\u003c\/h3\u003e\n\u003cdiv class=\"o-ProductAdditionalInformation u-clearfix\"\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003e19.06 mg calcium folinate-5 water\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3 class=\"a-h4 u-no-margin u-font-weight--bold\"\u003e\u003cspan\u003eexcipients\u003c\/span\u003e\u003c\/h3\u003e\n\u003cdiv class=\"o-ProductAdditionalInformation u-clearfix\"\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003elactose-1 water\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ecellulose powder\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCarboxymethyl Starch, Sodium\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCorn starch, pregelatinized\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003emagnesium stearate\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eindication\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eThe medicine is a detoxifying agent when using certain medicines to treat cancer and a means of preventing folic acid deficiency symptoms.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eThe medicinal product is used for\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003e1. Prevention of symptoms of poisoning with (medium) high-dose methotrexate therapy or persistently high methotrexate serum levels (also with low-dose methotrexate therapies).\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eA notice:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003ePersistently high methotrexate serum levels are to be expected in particular in the case of pleural effusions, ascites, renal insufficiency and insufficient fluid intake during methotrexate therapy.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e2. Treatment of symptoms of intoxication from methotrexate therapy that can be attributed to tetrahydrofolic acid deficiency.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003e3. Treatment of folic acid deficiencies of various causes that cannot be remedied by dietary measures.\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eHints:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eWith this treatment, a vitamin B12 deficiency should be excluded in the differential diagnosis.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIn contrast to the areas of application mentioned under 1. and 2., the use of folic acid is sufficient here.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003edosage\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eAlways take this medicine exactly as described or as your doctor or pharmacist has told you.\u003cspan\u003e \u003c\/span\u003eCheck with your doctor or pharmacist if you are not sure.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eThe preventive use of previous methotrexate use in cancer therapy is reserved for physicians who have sufficient experience in high-dose methotrexate therapy.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eUnless otherwise prescribed by the doctor, the usual dose is:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003e1) in the prevention of symptoms of intoxication caused by tetrahydrofolic acid deficiency in methotrexate therapy (calcium folinate rescue):\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eFrom a methotrexate dosage of about 100 mg\/m\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e2\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003ebody surface area (BSA), this treatment must be followed by the administration of calcium folinate.\u003cspan\u003e \u003c\/span\u003eThere are no uniform recommendations for the dosage and type of application of calcium folinate as an antidote in high-dose methotrexate shock therapy, so the following dosage recommendations are given as examples:\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eCalcium folinate rescue after methotrexate (MTX) therapy:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eMTX serum level 24 - 30 h: 1 x 10\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e-8\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003emol\/l to \u0026lt; 1.5 x 10\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e-6\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003emol\/l\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eCalcium folinate dose: 10 - 15 mg\/m\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e2\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003eBSA every 6 hours\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDuration: 48 hours\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eMTX serum level 24 - 30 hours: 1.5 x 10\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e-6\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003emol\/l to 5 x 10\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e-6\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003emol\/l\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eCalcium folinate dose: 30 mg\/m\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e2\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003eBSA every 6 h\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eDuration: until the plasma level is \u0026lt; 5 x 10\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e-8\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003emol\/l\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eMTX serum level 24 - 30 hours: \u0026gt; 5 x 10\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e-6\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003emol\/\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eCalcium folinate dose: 60 - 100 mg\/m\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e2\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003eBSA every 6 hours\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eDuration: until the plasma level is \u0026lt; 5 x 10\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e-8\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003emol\/l\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCalcium folinate is used orally.\u003cspan\u003e \u003c\/span\u003eHowever, patients with absorption disorders (e.g. vomiting) must be excluded from oral calcium folinate rescue.\u003cspan\u003e \u003c\/span\u003eThe absorption of orally administered calcium folinate is subject to a saturation mechanism.\u003cspan\u003e \u003c\/span\u003eWith oral administration of calcium folinate doses above 40 mg, the bioavailability is reduced.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eBeginning of calcium folinate protection:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eNo later than 18-30 hours after the start of the methotrexate infusion.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eEnd of Calcium Folinate Protection:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eNot earlier than 72 hours after the start of the methotrexate infusion.\u003cspan\u003e \u003c\/span\u003eUpon termination of calcium folinate use, the methotrexate serum level should be below 10\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e-7\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003emol\/l, preferably below 10\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e-8\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003emol\/l.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eA dosage that goes beyond the protective function (\"over-rescue\") can lead to impairment of the effectiveness of methotrexate. If protection is insufficient, high-dose methotrexate shock therapy can lead to considerable toxic side effects (see instructions for use of methotrexate-containing medicines).\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003e2) in the treatment of symptoms of intoxication from low-dose methotrexate therapy (single dose \u0026lt; 100 mg\/m\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003csup\u003e\u003cspan\u003e2\u003c\/span\u003e\u003c\/sup\u003e\u003cspan\u003e\u003cspan\u003e \u003c\/span\u003eKO), which can be attributed to tetrahydrofolic acid deficiency:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eImmediately administer an amount of calcium folinate IV or IM equivalent to 6-12 mg of folinic acid.\u003cspan\u003e \u003c\/span\u003eThen apply the same dose several times (at least four times) at intervals of 3 to 6 hours.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eFor more intensive calcium folinate rescue in the case of delayed methotrexate excretion under medium-high or high-dose methotrexate therapy, reference is made to the specialist literature.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eA notice:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eIf the poisoning is caused by a significantly delayed excretion (e.g. [acute] kidney failure), dialysis can be considered.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eTo note:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eThe prophylactic administration of calcium folinate in methotrexate therapy requires the possibility of determining the methotrexate serum level.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003e3) in the treatment of folic acid deficiencies:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003e5 mg (up to a maximum of 15 mg) of folinic acid daily.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eIf you take more than you should:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eNo special measures are required in the event of an overdose.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eIf you have any further questions on the use of this medicine, ask your doctor or pharmacist.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eway\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eFor ingestion.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eside effects\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eLike all medicines, this medicine can cause side effects, although not everybody gets them.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eThe following side effects have been observed:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eRare (may affect up to 1 in 1,000 people)\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eIncrease in seizure frequency in patients with epilepsy\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003edepression\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003erestlessness\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDisorders of the digestive system\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003esleep disorders (insomnia)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eVery rare (may affect up to 1 in 10,000 people)\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003esevere allergic reaction - you may have a sudden itchy rash (hives), swelling of your hands, feet, ankles, face, lips, mouth or throat (which may cause difficulty in swallowing or breathing), or fainting.\u003cspan\u003e \u003c\/span\u003eIt's a serious side effect.\u003cspan\u003e \u003c\/span\u003eYou may need urgent medical treatment.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ewheals (urticaria)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eNot known (cannot be estimated from the available data)\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003etoxic epidermal necrolysis (TEN): severe skin reaction including loss of skin\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eStevens-Johnson syndrome (SJS): severe skin reaction with a blistering rash and skin inflammation, particularly on the hands, feet and around the mouth, accompanied by fever.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIf you get any side effects, talk to your doctor or pharmacist.\u003cspan\u003e \u003c\/span\u003eThis also applies to side effects that are not specified.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003einteractions\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eTaking with other medicines\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eTell your doctor or pharmacist if you are taking\/using, have recently taken\/used or might take\/use any other medicines.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eCalcium folinate\/ methotrexate\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eFor specific details on reducing methotrexate toxicity, please refer to the methotrexate package insert.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eThe preparation has no effect on non-blood toxicity of methotrexate (non-haematological toxicity), such as toxicity to the kidney (nephrotoxicity, as a result of methotrexate and\/or the precipitation of methotrexate degradation products in the kidney).\u003cspan\u003e \u003c\/span\u003ePatients with delayed early elimination of methotrexate (methotrexate elimination) have a high probability of developing reversible renal failure and all methotrexate-related toxicities (please see methotrexate package insert).\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eExcessive doses of calcium folinate must be avoided as they can reduce the antitumor activity of methotrexate.\u003cspan\u003e \u003c\/span\u003eThis is particularly true in tumors of the central nervous system, in which the active substance of calcium folinate accumulates after repeated courses of treatment.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eInsensitivity to methotrexate (methotrexate resistance) as a result of reduced transport across the membranes into the cells also suggests resistance to calcium folinate treatment since both drugs have the same transport mechanism.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAn accidental overdose of a cancer drug like methotrexate should be treated as a medical emergency.\u003cspan\u003e \u003c\/span\u003eThe longer the time interval between methotrexate use and calcium folinate treatment (calcium folinate rescue), the less effective calcium folinate is as a countermeasure to reduce toxicity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eThe possibility that the patient is taking other drugs that interact with methotrexate (eg, drugs that interfere with methotrexate elimination or binding to serum albumin) should always be considered if laboratory abnormalities or clinical toxicities are observed.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eCalcium folinate\/ 5-fluorouracil\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eCalcium folinate can increase the toxicity of fluorouracil.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eCalcium folinate\/ chloramphenicol\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eThe concomitant use of chloramphenicol and folic acid in patients with a folic acid deficiency is not recommended, as it can negate the effectiveness of folic acid.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eCalcium folinate\/ other folic acid antagonists\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eSimultaneous therapy with a folic acid antagonist (e.g. cotrimoxazole, pyrimethamine) and calcium folinate is not recommended, since the effectiveness of the folic acid antagonist can either be reduced or completely reversed.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eCalcium folinate\/other medicines\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eCalcium folinate may reduce the effects of the antiepileptic drugs phenobarbital, primidone, phenytoin and succinimide, leading to an increase in seizure frequency.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eContraindications\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eThe drug must not be taken\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eif you are allergic to calcium folinate, folic acid or any of the other ingredients;\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eif you suffer from malignant anemia: calcium folinate is not suitable for treating malignant anemia and other anemias caused by vitamin B12 deficiency;\u003cspan\u003e \u003c\/span\u003eAlthough improvements in the blood count can occur, the symptoms on the part of the nervous system continue to progress.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePlease refer to the \"Pregnancy Advice\" category regarding treatment of pregnant or breastfeeding women with calcium folinate and methotrexate or fluorouracil.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePlease also note the package leaflets for medicines containing methotrexate and other medicines containing folic acid antagonists and fluorouracil if you are taking or using them.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003epregnancy and breast feeding period\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eIf you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eWhat needs to be considered during pregnancy if\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eonly calcium folinate is used (monotherapy)?\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eThere is no evidence that the active ingredient folinic acid causes harmful effects when given during pregnancy.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eCalcium folinate is used with other medicines?\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eMethotrexate (a drug used in cancer therapy) should only be used during pregnancy if there is a strong indication that the benefit of the drug to the mother is weighed against the possible risk to the foetus.\u003cspan\u003e \u003c\/span\u003eIf treatment with methotrexate or other folic acid antagonists takes place despite pregnancy or lactation, there are no restrictions with regard to the use of the preparation to reduce toxicity or to counteract the effects.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eWhat must be considered during breastfeeding?\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eIt is not known whether the active substance calcium folinate is excreted in human breast milk.\u003cspan\u003e \u003c\/span\u003eCalcium folinate can be used during lactation if considered necessary based on the therapeutic indications.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eThe use of fluorouracil is generally not indicated during pregnancy and breast-feeding;\u003cspan\u003e \u003c\/span\u003ethis also applies to the combined use of calcium folinate with fluorouracil.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePlease also read the package leaflets for medicines containing methotrexate and other folic acid antagonists and fluorouracil if you are taking or using them.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003epatient notes\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eWarnings and Precautions\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003ePlease talk to your doctor or pharmacist before taking this medicine.\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eIf you have epilepsy and are being treated for it:\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eIn epileptics treated with the active substances phenobarbital, phenytoin, primidone and succinimides there is a risk that the frequency of seizures will increase due to a decrease in the plasma concentrations of the antiepileptic drugs.\u003cspan\u003e \u003c\/span\u003eClinical monitoring is recommended during use of calcium folinate (the active substance in Leucovorin) and after stopping it, possibly monitoring the amount of active substance in the blood plasma (plasma levels) and, if necessary, adjusting the dose of the antiepileptic drug.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003eGeneral\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eCalcium folinate should be used with methotrexate only under the direct supervision of a physician experienced in the use of cancer chemotherapy drugs.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eTreatment with calcium folinate can mask malignant anemia and other anemias caused by vitamin B12 deficiency.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMany cytotoxic drugs - direct or indirect inhibitors of the synthesis of the hereditary substance DNA - lead to an enlargement of the red blood cells (macrocytosis) (hydroxycarbamide, cytarabine, mercaptopurine, thioguanine).\u003cspan\u003e \u003c\/span\u003eSuch macrocytosis should not be treated with this preparation.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003eAbility to drive and use machines\u003c\/span\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eThere is no evidence that the preparation affects the ability to drive or use machines.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"Pfizer Pharma GmbH","offers":[{"title":"Default Title","offer_id":54928727409017,"sku":"01929399","price":295.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0903\/0792\/0249\/files\/leucovorin-15-mg-tablets-10-pc-calcium-folinate-uk.jpg?v=1738780368","url":"https:\/\/ukdorf.co.uk\/products\/leucovorin-15-mg-tablets-10-calcium-folinate","provider":"UKDorf (ELIVERA) Buy online, Reviews Est. 1988 London, UK.","version":"1.0","type":"link"}